These findings suggest that supplementation with selenium during pregnancy might be an effective approach for the prevention of postpartum depression.

Kinesin proteins are critical for various cellular functions such as intracellular transport and cell division, and many members of the family have been linked to monogenic disorders and cancer. We report eight individuals with intellectual disability and microcephaly from four unrelated families with parental consanguinity. In the affected individuals of each family, homozygosity for likely pathogenic variants in KIF14 were detected; two loss-of-function (p.Asn83Ilefs*3 and p.Ser1478fs), and two missense substitutions (p.Ser841Phe and p.Gly459Arg). KIF14 is a mitotic motor protein that is required for spindle localization of the mitotic citron rho-interacting kinase, CIT, also mutated in microcephaly. Our results demonstrate the involvement of KIF14 in development and reveal a wide phenotypic variability ranging from fetal lethality to moderate developmental delay and microcephaly.

Objectives: To evaluate effectiveness of combined treatment with cervical pessary (CP) and vaginal Progesterone (VP) for the prevention of preterm birth in singleton pregnancies with cervical consistency index (CCI) ≤ 5th percentile at 11-13 weeks' gestation. Methods: Prospective study from January 2016 to February 2017 was performed and transvaginal CCI and cervical length (CL) measurement were taken at 11-13.6 weeks' gestation in 615 singleton pregnancies. Patients with CCI ≤ 5th percentile were offered combined treatment with CP and VG 200 mg/day. VP was given until 34 weeks; CP was removed at 36 weeks or at the onset of labour. Patients with uterine contractions, bleeding or premature rupture of membranes were excluded. Preterm birth defined as born before 37 weeks of gestation, was match (1:3) by gestational age and CCI. Results: 36 pregnant women of study group (who received treatment) had an average CL measurement of 37.4 mm, CCI of 51% and the mean gestational age at enrolment was 12.3 weeks compared to the control group (12 patients who did not receive treatment) 40.4 mm, 53% and 12.1 weeks respectively. Combined treatment compared to no treatment was associated with a statistically significant increase at the gestational age at delivery (33.3 VS 28.4 weeks; p <0.001). Conclusions: Combined treatment with CP and VP in singleton pregnancies with CCI ≤ 5th percentile at 11-13.6 weeks increases the gestational age at delivery. Supporting information can be found in the online version of this abstract P01.08 Comparison of preventive measures for preterm deliveries in twin pregnancies between pessary-progesteron and cerclage alone Objectives: To compare the combination of pessary-progesterone and cerclage in twin pregnancies with high risk of preterm delivery. Methods: Between 2006 and 2016, all twin pregnancies at a tertiary referral centre in Ankara for high-risk pregnancies were reviewed. All those etiology of preterm twin deliveries were investigated and different preventive measures for preterm deliveries were compared. High-risk of preterm delivery by obstetric history and cervical assessment of transvaginal ultrasonography was determined. Cervical length less than 25mm were considered high-risk for preterm delivery. Chi-square, Fisher's, Student T-test and Mann-Whitney U tests were used for the statistical analyses. P value less than (p>0.05) is considered statistically significant. Results: Total number of twin pregnancies were found to be 6.7% (449/6727). Of those, 32.1% (144/449) and 79.9% (359/449) were delivered before 34 weeks and 37 weeks of gestation, respectively. Among the high-risk patients, two different approaches to prevent preterm birth were compared. Cerclage (Group I) was used on 21 patients and Pessary-Progesteron (Group II) together was performed on 21 patients too. Total of 395 twin pregnancies were without cerclage or pessary-progesteron. The mean age of the groups were 32 in both groups. There was no statistical difference between the groups in terms of obstetric history (gravida...

Our findings indicate that selenium supplementation in pregnant women may be associated with a lower frequency of preeclampsia.

Premature rupture of the membranes (PROM) occurs in about 8-10% of pregnancies and its most important complication is chorioamnionitis, so labour induction has an important role in this situation. This study was performed to compare oxytocin and sublingual Misoprostol for labour induction in PROM cases with term pregnancy. A total of 270 pregnant women who had spontaneous rupture of membrane and unripe cervix were enrolled. The first group underwent Oxytocin infusion according to low-dose standard protocol and the second group received 25 μg sublingual Misoprostol every 4 h. Time interval from induction to the beginning of active phase of labour was similar in both groups. Second stage of labour was significantly shorter in misoprostol group (p < .05). Although, some maternal side-effects were significantly higher in misoprostol group (p < .001), but 5 minute Apgar score was significantly better in this group. In conclusion, sublingual misoprostol was associated with better neonatal outcomes was more effective than oxytocin for labour induction in PROM cases. Impact statement What is already known on this subject: PROM occurs in about 8-10% of pregnancies; about 60% of these cases are term pregnancies. Most experts recommend early induction of labour in term PROM cases with an eye towards avoiding increased morbidity and mortality. Oxytocin is the most frequently used agent that is administered intravenously for the purpose of labour induction. Misoprostol is an alternative to oxytocin and is simpler to use, as it is administered via the oral, buccal, sublingual, rectal and vaginal routes rather than intravenously. What do the results of this study add: Time interval from induction to the beginning of active phase of labour was similar in both groups. Second stage of labour was significantly shorter in the misoprostol group. Although, some maternal side-effects were significantly higher in misoprostol group, the 5 minute Apgar score was significantly better in this group. What are the implications of these finding for clinical practice and/or further research: Sublingual misoprostol for induction of labour in PROM cases is more effective than oxytocin and its neonatal outcomes are better. Due to its easy prescription and better labour outcomes, sub lingual misoprostol may be a better choice for labour induction in PROM cases.