INTRODUCTION & AIM: Identification of effective factors on job satisfaction can impact the efficiency and quality of health services and personal life. The Aim of this study was to investigate, Job Satisfaction and External Effective Factors in Operating Room Nurses Educational Hospitals of Zahedan in 2015.MATERIALS & METHODS: This descriptive–analytical study was conducted on 137 operating room Nurses of Ali-Ebne-Abitaleb, Khatam-Al-Anbia and Alzahra hospital in Zahedan, Iran, enrolled through the convenience sampling in 2015. The data were collected by the valid and reliable job satisfaction standard questionnaire or Herzberg's Dual-Factor theory. To analyze the information, descriptive statistics, Chi-square & Pearson correlation test were applied by use of SPSS v. 21 software.FINDINGS: The results found that the most effective factors of job satisfaction were job safety with an average 4/78, work qualification with an average 4/32 and suitable salary with an average 3/91 respectively. Only 45.98% of the nurses experienced moderate job satisfaction, and only 25.54% of them had high job satisfaction. Moreover, job satisfaction was significantly related to the type of employment (p=0. 019), work background (p=0. 029) and turn of work (p=0. 034).CONCLUSION: The data of this study found that, notice and planning in preparing job safety, work qualification and proper salary may play a more effective role in improving employees’ performance than any other factors.