Performance enhancement and cost-effectiveness are the critical factors for most industries. There is a variation in the performance and cost matrices based on the industrial sectors; however, cybersecurity is required to be maintained since most of the 4th industrial revolution (4IR) are based on technology. Internet of Things, IoT, technology is one of the 4IR pillars that support enhancing performance and cost. Like most Internet-based technologies, IoT has some security challenges mostly related to access control and exposed services. Artificial intelligence (AI) is a promising approach that can enhance cybersecurity. This chapter explores industrial IoT (IIoT) from the business view and the security requirements. It also provides a critical analysis of the security challenges faced by IoT systems. Finally, it presents a comparative study of the advisable AI categories to be used in mitigating IoT security challenges.