A series of six - membered rings has been synthesized from Dapsone drug. In the first step examination Dapsone has been taken as initial material and treated with different aromatic aldehydes to prepare new Schiff bases compounds. then imine compounds react with (2-aminobenzoic acid and 2-mercaptobenzoic acid) to prepare Hydroqinazoline and Thiazinone derivatives. In the second step all these derivatives were tested against different bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus anthracis). The high efficacy results of these derivatives proved significantly greater than the efficacy of the same Dapsone drug. These compounds were identified and confirmed by FT- IR, 1HNMR and 13C-NMR.

A series of four- membered rings has been synthesized from Dapsone drug. In the first step examination Dapsone has been taken as initial material and treated with 4-aminoacetophenone to prepare new Azo compound. then Azo compound reacts with various aromatic amines in absolute ethanol to prepare Schiff bases derivatives. In the second step these derivatives react with Chloroacetylchloride in the presence of tri ethyl amine(Et3N) to prepare new four- membered heterocyclic compounds . All these derivatives were tested against different bacteria(Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus anthracis). The high efficacy results of these derivatives proved significantly greater than the efficacy of the same Dapsone drug.These compounds were identified and confirmed by FT- IR, 1HNMRand 13C-NMR.