An ischemic stroke is characterized by the brutal installation of a focal functional deficit. Myxomas are the most common primitive cardiac tumors. Neurological manifestations of myxomas are mostly related to cardioembolic events, either caused by a migrating fragment of the tumor or by an attached clot that got detached from the tumor This article describes the case of a 55-year-old male who presented with an ischemic stroke of the vertebrobasilar territory. Cardiac exploration revealed the presence of a cardiac mass. The patient was surgically treated and the anatomopathological study confirmed the diagnosis of cardiac myxoma. This case emphasizes the obligation to research the etiology of ischemic strokes, and more importantly the realization of a complete cardiologic exploration.