Abstract. Considered as the second men cancer in Algeria, prostate cancer is treated in 70% by radiation. That's why radiation therapy is therapeutic weapon for prostate cancer. Conformational Radiotherapy in 3D is the most common technique [1−5]. The use of conventionally optimized treatment plans was compared at case scenario of optimized treatment plans VMAT for prostate cancer. The evaluation of the two optimizations strategies focused on the resulting plans ability to retain dose objectives under the influence of patient set up. Dose Volume Histogram in the Planning Target Volume and dose in the Organs At Risks were used to calculate the conformity index, and evaluation ratio of irradiated volume which represent the main tool of comparison [6,7]. The situation was analysed systematically. The 14% dose increase in the target leads to a decrease in the dose in adjacent organs with 39% in the bladder. Therefore, the criterion for better efficacy and less toxicity reveal that VMAT is the best choice.

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Hadrontherapy represents a pioneer technique, and only few centers worldwide can provide this advanced and specialized cancer treatment. Geant4 (GEometry ANd Tracking 4) is a C++, free and open toolkit that used to simulate the interaction of particles in matter. It is employed in various fields from highenergy physics, nuclear physics to medicine. By means of Monte Carlo simulation tool Geant4, we have simulated the hadrontherapy beam line typical of a proton-therapy line modeled in the category of the advanced examples with all its elements: the diffusers, range shifters, collimators and detectors. This Simulation has permited the calculation of dose and Linear Energy Transfer (LET). In this context, this study reports the first results of our simulation realized by means of Geant4 10.2 version and their comparizon with those obteined by Cironne.