This study included the Zakhikhah area in the Al- Anbar desert, which it bounded on the north, east, and west by the Euphrates River and on the south by the Ramadi-Qaim road. Several exploratory field trips were taken to the study area. During this time, a semi-detailed area survey was carried out based on satellite imagery captured by American Land sat-7, topographic maps, and natural vegetation variance. All necessary field tools, including a digital camera and GPS device, were brought to determine the soil type and collect plant samples. All of these visits are planned to cover the entire state of Zakhikhah. All vegetation cover observations, identifying sampling sites and attempting to inventory and collect medicinal plants in the study area at all stages were recorded. The reasons for the variation in the distribution of medicinal plants in the Zakhikhah area were also presented in this study concerning their distribution sites. The total number of species collected in all stages, according to the findings of this study, was 12. The most abundant plant was the hibiscus, which accounted for 35.40% of the total area and covered 4210.8 acres. The samples were identified, named, and preserved in the University of Anbar’s College of Education for Pure Sciences/Department of Life Sciences herbarium. How to Cite: Fatin H. Al-Dulaimi, 2023. "Distribution and Classification of Medicinal Plants in Zakhikhah Area of Al-Anbar Desert." Journal of Agriculture and Crops, vol. 9, pp. 257-265.