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Periodontitis is one of the common dental diseases that cause loss of teeth and adversely affects mastication and consequently the quality of life. Therefore, arresting the progression of periodontal diseases and the reconstruction of damaged tissues is the main concern. There are several strategies and (bio) materials already have been tried to achieve this goal, but the main obstacle was to find a unique biomaterial that can fulfill the tissue engineering criteria to ensure successful and reliable regenerative outcomes. Platelet-derived biomaterials (platelet concentrates) are widely used natural autologous biomaterials and show promising implementation due to their desired results in wound healing and tissue regeneration.