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These findings indicated that the dose of 20 Gy in 10 fractions radiotherapy caused neuropathic damages in normal rat sciatic nerve 3 and 6 months after irradiation.

electronic) 0250-4685 (printed) 239Effect of Funalia trogii in heart tissue of rats exposed to deltamethrin [Deltametrine maruz kalan sıçanların kalp dokusunda Funalia trogii'nin etkisi] Research Article [Araştırma Makalesi] Türk Biyokimya Dergisi [Turkish Journal of Biochemistry-Turk J Biochem] 2012; 37 (3) ; 239-244. Yayın tarihi 30 Eylül, 2012 © TurkJBiochem.com [ ABSTRACTObjective: Environmental exposure to deltamethrin can cause alterations in structure and function of different organs. F. Trogii, a white-rot fungus, has antioxidative enzymes such as superoxide dismutase, catalase and glutathione reductase. It is hypothesized that there is an antioxidative role of F. trogii resulting in reducing the extent of heart injury as a result of oxidative stress. The aim of this study to investigate the effect of deltamethrin on heart and to evaluate possible protective role of F. trogii in alleviating the detrimental effect of deltamethrin on heart. Materials and Methods: Twenty-one adult albino female Wistar rats were randomly divided into three groups of seven each: group 1 control, group 2 received deltamethrin, group 3 received deltamethrin plus F. trogii extract. Results: The heart rate was increased and amplitude of QRS complex, duration of P wave and QRS complex were decreased due to deltamethrin administration. The superoxide dismutase and catalase activities were decreased, malondialdehyde level was increased in deltamethrin group. Ultrastructurally, dilatation in sarcoplasmic reticulum cisternaes and disorganisation in the myofibrils were observed in the deltamethrin group. In the deltamethrin plus F. trogii extract group, a decreasing lipid peroxidation and an increasing antioxidant enzyme activity, normal heart electrical activity and normal heart muscle structure was observed as similar to control group Conclusion: F. trogii could protect against deltamethrin induced oxidative stress by decreasing lipid peroxidation and increasing superoxide dismutase and catalase activity. The results indicate the protective effect of F. trogii against heart injury and thereby support its traditional use.

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