Background: Total immunoglobulin E (IgE) has roles in allergy and anti-parasitic immunity. Recently IgE showed a major role in cancer immune surveillance; an increased risk of solid and blood malignancies has been associated with total IgE deficiency. This study aimed to determine the level of serum total IgE in colorectal carcinoma (CRC) patients and its association with CRC staging. Methods: This case-control study included 60 patients with newly diagnosed CRC and 60 healthy age and sex-matched controls. All participants were subjected to detailed medical history taking, physical examination, assessment of CRC stages, complete blood count and serum total IgE level. Results: Regarding CRC patients, the mean (± SD) age was 53.18 ± 13.52 years, 34/60 patients were males, The median (IQR) total IgE level was 42.5 (22.5 -77.5) IU\ml. Six CRC patients had a total IgE level ≤ 5 IU\ml, 43 patients had a total IgE level 6-100 IU\mL, and 11 patients with a total IgE level >100 IU\mL. Twenty CRC patients were stage II, 19 patients were stage III, and 21 were stage IV. 53/60 CRC patients were diagnosed with adenocarcinoma. 40/60 patients had colonic carcinoma and 18 patients had rectal carcinoma. There was statistical significance between cases and controls regarding the level of total IgE (p-value <0.05). There was no significant association between total IgE levels and CRC stages, histopathological findings, nor anatomical sites. Conclusions: Total IgE levels may play a role in CRC, with statistical significance between CRC patients and controls but no correlation with CRC stages.