The present study was aimed to investigate the possible biochemical and histopathological effects of benzene on the liver and kidney of male albino rat. Hepatic and renal indices such as alanine and aspartate aminotransferases and alkaline phosphatase, as well as creatinine, urea and uric acid were used as markers of study. Biochemical estimation of hepatic enzymes and renal indices were significantly increased compared to control and confirmed the histopathological results which showed both hepatic and renal damage. It b concluded that the ingestion of benzene-contaminated food showed a deleterious effect the liver and kidney at the employed doses and for the use period.