Potential biologically active derivatives of the 2-Amino-5-aryl or Formylpyridine-3-Carbonitriles (2a-d) were prepared by the cyclocondensation reaction of vinamidinium salts with malonitrile. The structures of these compounds were established on the basis of elemental (C, H,N) and spectral (1 H-NMR, 13 C-NMR and spectral data) analysis. The compounds were screened for their antifungal and antibacterial activity. The compound 2-amino-5-formylpyridine-3-carbonitrile was found to be the most potent compound of series.

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The symmetrical vinamidinium salts were allowed to react with malononitrile in refluxing ethanol in the presence of ammonium acetate for 12 h to afford the 2‐amino‐5‐aryl or formylpyridine‐3‐carbonitriles.

via a multicomponent reaction

Convenient Synthesis of Pyrazolo[3,4-b]pyridin-3-ones and Pyrazolo[3,4-b]pyridine-5-carbaldehydeUsing Vinamidinium Salts. -(SAMAR, C.; FAYCEL, J.; JAMELEDDINE*, K.; Tetrahedron Lett. 52 (2011) 28, 3648-3650, http://dx.