Background: Personal Hygiene includes all activities required to meet the needs of day-to-day, which is commonly known activity of daily life (ADLs). The issue of personal hygiene or self-care deficit is the most common problem occured in mental patients, because patients with mental disorders have the abnormalities in the ability to perform or complete activities of daily living independently. Objective: To determine the relationship between family support and personal hygiene of mental patients in Wara Public Health Centre, Palopo in 2020. Method: This study used the cross-sectional research method. The population in this research was all mental patients registered on Wara Public Health Centre. The samples was recruited using a total sampling technique obtaining 43 respondents. Data were collected using questionnaire sheet and observation. The data obtained were processed and analyzed by using Microsoft Excel program and statistical program (SPSS) version 20 for the Chi-square test. Result: The univariate analysis showed the frequency distribution, while bivariate analysis showed a relationship between family support and personal hygiene (? = .003). Conclusion: There is a relationship between family support and the personal hygiene of mental patient in Wara Public Health Centre, Palopo City in 2020