Schizophrenia is a mental disorder that is quite widespread in nature in Indonesia, which is about 99% of patients, the mental hospital in Indonesia are people with schizophrenia. The highest prevalence of psychosis is in DIY is 2.7 per 1000 population. Based on the data reports the top 10 disease hospitalization from January to June 2015 at the Mental Hospital Grhasia DIY disease schizophrenia is a disease with a high of 371 while other mental disorders as many as 54 people. This study aimed to determine risk factors of schizophrenia in patients hospitalized in the Psychiatric Hospital Grhasia DIY. This research was an analytic observational with cross sectional design. The sample was 79 people schizophrenia and non-schizophrenia. Data analysis was using Fisher's Exact Test. There were relationships between heredity RP = 1.195 (95% CI 1.004 to 1.423), psychosocial stressors of interpersonal relationship problems RP = 1.257 (CI95% from 1.056 to 1.497), psychosocial stressors of family factors RP = 1.366 (CI95% from 1.063 to 1.756) to the incidence of schizophrenia in-patients at the Mental Hospital Grhasia DIY. This research concluded that heredity, psychosocial stressors of interpersonal relationship problems and family factors are risk factors of the incidence of schizophrenia in the Mental Hospital DIY.