Intravitreal ranibizumab injections used to treat AMD caused a significant change in RNFL thickness after 12 months of follow-up.

The RBT overestimates the IOP compared with the Perkins tonometer in patients with congenital glaucoma. Differences in readings between the 2 tonometers become larger as the CCT increases.

To evaluate the concentrations of pro-inflammatory cytokines in tear and aqueous humour of patients with primary open-angle glaucoma (POAG), relative to healthy controls. Method: Tear and aqueous humour samples were collected from 29 healthy controls and 27 POAG patients. Twenty-seven inflammatory cytokines were analysed: interleukin (IL)-

ObjectiveTo analyse the morphological features and diagnostic ability of eight macular retinal layers using a new segmentation software Heidelberg's Spectralis Optical Coherence Tomography (SD-OCT) in healthy, ocular hypertensive and primary open angle glaucoma patients.MethodsSingle-center, cross-sectional, non-interventional study. 193 eyes from 193 consecutive patients (56 controls, 63 ocular hypertensives, 32 early primary open glaucoma patients and 42 moderate-advanced primary open glaucoma patients). Those patients presenting any retinal disease were excluded. Macular segmentation of the retinal layers was automatically performed using the new segmentation Heidelberg's Spectralis OCT software providing measurements for eight retinal layers. The software provides thickness maps divided into nine subfields.ResultsStatistically significant differences in inner layers’ thickness was found between all 4 four groups. Superior and inferior sectors of macular retinal nerve fiber layer; nasal, temporal, superior and inferior sectors of ganglion cell layer and inner plexiform layer were significantly different when comparing ocular hypertensive patients and early glaucoma patients. Areas under the ROC curves for early glaucoma diagnosis were 0.781±0.052 for macular retinal nerve fiber layer outer inferior sector, 0.760±0.050 for ganglion cell layer outer temporal sector, 0.767±0.049 for the inner plexiform layer outer temporal sector and 0.807±0.048 for the combination of all three. No differences were found between groups when considering outer retinal layers.ConclusionsThe automated segmentation software from Heidelberg's Spectralis OCT provides a new diagnostic tool for the diagnosis of ocular hypertensive and glaucoma patients.