The aim of this study is to evaluate the prevalence of overweight and central obesity among Anhanguera Uniderp School of Medicine undergraduates in the city of Campo Grande, state of Mato Grosso do Sul, and the possible related variables, according to socio-demographic data like life habits, and personal and family background. A cross-sectional quantitative observational study was conducted with a sample of 295 undergraduates who filled a survey questionnaire form, and Overweight and obesity were measured by using body mass index (BMI). Central obesity was measured by waist circumference: ≥88 cm for females and ≥102 cm for males. Results presented prevalence rates of 26.4% for overweight, 7.8% for obesity and 7.5% for central obesity. There was a significant association between overweight and central obesity with childhood obesity, family history of obesity, and the habitual intake of animal fats. There was a significant association of overweight with the regular intake of alcohol, approximately 3-4 times/week, and less than 2 hours of extracurricular study. The prevalence of overweight among UNIDERP medical students is high and similar to the national population for the same age group.