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Artaboterpenoids A and B (1 and 2), two novel bisabolene-derived sesquiterpenoids, were isolated from the roots of Artabotrys hexapetalus. Their structures with absolute configurations were elucidated by spectroscopic methods, and electronic circular dichroism (ECD) analyses. Notably, 1 featured a novel carbon skeleton with a new C-2-C-10 linkage, and 2a and 2b, a pair of enantiomers, represented the first examples of 1,2-seco-bisabolene-type sesquiterpene lactones. 2a exhibited cytotoxic effects against HCT-116, HepG2, A2780, NCI-H1650, and BGC-823 cell lines with IC50 values of 1.38-8.19 μM. Plausible biogenetic pathways for artaboterpenoids A and B were proposed.

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Three new olean-type triterpenoid saponins, namely 3-O-(2-O-acetyl-β-D-glucopyranosyl) oleanolic acid-28-O-(β-D-glucopyranosyl) ester (1), 3-O-(6-O-acetyl-β-D-glucopyranosyl) oleanolic acid-28-O-(β-D-glucopyranosyl) ester (2) and 3-O-(β-D-glucopyranosyl) oleanolic acid-28-O-(6-O-acetyl-β-D-glucopyranosyl) ester (3), were isolated from the aerial parts of Eclipta prostrata (L.). Their structures were elucidated based on 1D and 2D NMR and MS spectroscopic data.