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Hypochlorous acid (HClO) is closely related to many diseases and is an inevitable part of physiological processes. It is significant to detect HClO in mitochondria for getting meaningful physiological and...

Endogenous carbon monoxide (CO) is mainly derived from degraded heme owing to HO-1 expression, which acts as a pivotal part in vasodilation and neurotransmitter, anti-inflammatory and anti-apoptosis process. Due to...

As an essential gasotransmitter, carbon monoxide (CO) had gradually become a research hotspot in that it possessed important physiological functions and unique pharmacological properties. However, to date, no report has focused on the topic of detecting CO both in vivo and using films. To open up a new field of CO probes, for the first time, we designed a probe (PMAH-CO) that showed a distinctive ratio emission characteristic and displayed the quantitative distribution of CO in HeLa cells and zebrafish with a higher signal-to-noise ratio. Meanwhile, the fluorescent polysiloxanebased film (PMF) containing PMAH-CO exhibited an excellent response to CO. Due to the addition of the Si−O bond, the probe exhibited a broad transparency in the visible light range and had excellent photostability. Moreover, the probe was economically viable, easy to handle, and suitable for biological research. Hence, PMAH-CO and PMF would open up the road to broaden the application of silicone materials in the field of fluorescence imaging.