The development of “wise medical” is crucial to global carbon reduction. The medical sector not only has the moral obligation to reduce carbon emissions, but also has the responsibility to provide high-quality services to patients. Existing research mostly focuses on the relationship between low-carbon and wise medical, while ignoring the transformation of wise medical and patients’ opinions in the context of low-carbon transition. The paper crawls the text data of comments on the Zhihu platform (a Chinese platform similar to Quora), explores the focus of patients on wise medical through the co-occurrence analysis of high-frequency words, with a focus directly related to the role of wise medical treatment in carbon reduction, and designed a questionnaire accordingly. Using 837 valid questionnaires collected in Zhejiang Province, an XGBoost model was constructed to discuss the main factors affecting patient satisfaction, and the regional heterogeneity among the coastal area of eastern Zhejiang, the plain area of northern Zhejiang and the mountainous area of southwestern Zhejiang is discussed. The results show that patients’ focus on wise medical lies mainly in the convenience brought by digitalization and the actual medical effect, and the main factors affecting satisfaction with medical treatment are the flow of people in hospitals, optimization of the medical treatment process, the application of digital platforms, the quality of telemedicine services and the appropriate quality of treatment. In terms of regional differences in Zhejiang Province, wise medical is more developed in the plain area of northern Zhejiang, with better simplified medical treatment processes and the construction of a digital platform, while the mountainous areas of southwestern Zhejiang have better quality in telemedicine services despite the geographical environment. Eastern Zhejiang is somewhere in between.