A new procedure for the manufacture of cetirizine dihydrochloride
via the new intermediate 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)-N,N-dimethylacetamide dihydrochloride,
synthesized by O-alkylation of 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethanol
with 2-chloro-N,N-dimethylacetamide,
is elaborated. Hydrolysis of the resulting amide and subsequent salification
provided cetirizine dihydrochloride.
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