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Background: Malaria infection in pregnancy contributes to low birth weight through preterm delivery and intrau-uterine growth restriction (IUGR). Maternal haemoglobin concentrations were found lower in malaria infected than non-infected women and reduced haemoglobin was the main determinant of preterm delivery. This study aimed to investigate the effect of malaria infection on premature birth delivery. Subjects and Method: Meta-analysis ad systematic review was conducted by collecting published articles from Google Scholar, PubMed, Springer Link, and Science Direct databases, from year 2010 to 2020. Keywords used “malaria in pregnancy”, “malaria during pregnant AND preterm”, malaria during pregnant AND preterm AND cross sectional study AND adjusted ratio”. The inclusion criteria were full text, using cross sectional study design, and reporting adjusted odds ratio. The articles were selected by PRISMA diagram. The quantitative data were analyzed by Review Manager 5.3 using random effect model. Results: 6 articles reported that malaria infection in pregnant women increased the risk of premature birth delivery (aOR= 1.72; 95% CI= 1.15 to 2.57; p= 0.009). Conclusion: Malaria infection in pregnant women increases the risk of premature birth delivery. Keywords: malaria infection, premature birth delivery Correspondence: Feri Yuda Anggara. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: feriyudha90@gmail.com. Mobile: 085220426805. DOI: https://doi.org/10.26911/the7thicph.03.119