crucial. In this era of biologic therapies, misdiagnosis, and the use of inappropriate drugs in CTCL may lead to catastrophic outcomes. If dupilumab had a role in progression or histopathological presentation is unknown. More studies are needed, and a more accurate and careful indication of biologic therapies is imperative. CONFLICT OF INTEREST The authors declare no conflicts of interest. AUTHOR CONTRIBUTIONS Denis Miyashiro designed the research, gathered and analyzed the data, and wrote the majority of the manuscript. Ana Gabriela Vivarelli gathered and analyzed the data and wrote part of the manuscript. Fernanda Gonçalves gathered and analyzed the data and wrote part of the manuscript. Jade Cury-Martins analyzed the data. José Antonio Sanches designed the research, analyzed the data, and wrote part of the manuscript. All authors have read and approved the submitted version of the manuscript.

Subungual basal cell carcinoma (BCC) is a rare disorder associated with many factors, including contact with some topical and oral substances. A differential diagnosis and an early approach are important to minimize the functional damage of the limbs affected by this type of tumor. We report a case of subungual BCC in a 70-year-old woman that was managed by surgical excision. The patient’s medical history included the previous use of arsenic. We emphasize the contribution of an early diagnosis to achieve better treatment results in this instance.

O nevo sebáceo de Jadassohn (NSJ) é um hamartoma organoide da pele usualmente observado ao nascimento ou logo após. A localização mais comum é o couro cabeludo, no entanto, pode envolver outras áreas da cabeça e pescoço. Classicamente, apresenta-se como uma placa bem definida, composta por múltiplas pápulas confluentes amarelo-alaranjadas ou amarelo-acastanhadas. O desenvolvimento de neoplasias sobre o NSJ é bem documentado (10% a 30%), bem como sua possível associação com síndrome neurocutânea. Reportamos um caso exuberante de NSJ facial em paciente masculino, de 2 meses de idade e sua abordagem cirúrgica precoce. Realizamos uma breve revisão da literatura recente sobre o tema.

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