The hypoglycemic salicylate action has been related to an increased insulin secretion (Micossi, Pontiroli, Baron, Tamayo, Lengel, Bevilacqua, Raggi, Norbiato and Foa 1978). In this report we describe the effects of salicylate on the dynamics of glucose-induced insulin secretion, in the isolated perfused rat pancreas. Material and MethodsMale Wistar rats, weighing 200-300 g, were used, and in all cases were fasted overnight prior to each perfusion. Sodium salicylate 50 mg/100 g of body weight was injected subcutaneously, 90 min.

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