Deep brain stimulation may offer an effective treatment option for cerebral palsy-related dystonia, especially in those treated before skeletal maturity.

The penetration of daptomycin, a new lipopeptide antibiotic, into inflamed meninges ranged between 4.37 and 7.53% (mean, 5.97%). Daptomycin was very efficacious in the treatment of experimental pneumococcal meningitis, producing a decrease of ؊1.20 ؎ 0.32 ⌬log 10 CFU/ml ⅐ h in the bacterial titer of Streptococcus pneumoniae against a penicillin-resistant strain and of ؊0.97 ؎ 0.32 ⌬log 10 CFU/ml ⅐ h against a penicillinand quinolone-resistant strain found in cerebrospinal fluid (CSF). For both strains, daptomycin was significantly superior to the standard regimen of a combination of ceftriaxone with vancomycin, sterilizing 9 of 10 CSF samples after 4 h. In vitro, daptomycin produced highly bactericidal activity in concentrations above the MIC.

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The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.

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