Aging affects the human face by causing an array of complex microscopic and macroscopic volumetric changes in different face areas. [1][2][3][4] The most affected ones are the deep fat compartments in the middle of the cheek (fundamentally the deep medial cheek, or DMC) and the suborbicularis oculi fat (SOOF), where the signs of facial aging can be more clearly appreciated. 2,3
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