Potential biologically active derivatives of the 2-Amino-5-aryl or Formylpyridine-3-Carbonitriles (2a-d) were prepared by the cyclocondensation reaction of vinamidinium salts with malonitrile. The structures of these compounds were established on the basis of elemental (C, H,N) and spectral (1 H-NMR, 13 C-NMR and spectral data) analysis. The compounds were screened for their antifungal and antibacterial activity. The compound 2-amino-5-formylpyridine-3-carbonitrile was found to be the most potent compound of series.
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