The aim of this study is to analyze the scientific studies on Kangal fish spa (Kangal hot spring), which has an important place for the region, and to investigate the role of minerals in water in the treatment of psoriasis with theoretical studies. Material and Methods: The physical, chemical and biological properties of Kangal fish spa water were evaluated with the data obtained by scanning the literature. In addition, Ligands (minerals) in the spring water and targeted proteins in the selected membrane structure closest to the human body (6dvz; mus musculus membrane structure) were analyzed using Hex 8.0.0 insertion software. Results: According to the analysis of the data of the literature review results:The average temperature of Kangal hot spring water is 35 °C, pH 7.42, dissolved oxygen and free carbon dioxide values are 4.4 and 8.74 mgL -1 . The total flow rate of the pools is 130 Ls -1 and its radioactivity is 6 eman. The electrical conductivity was 530 μScm -1 and the total mineralization range was 590.9 mgL -1 . According to the Hex 8.0.0 placement program, selenium and magnesium gave negative E values of E=-10.28 kcalmol -1 , E=-36.91 kcalmol -1 . Conclusion:The literature analysis and the evaluation of the data of theoretical studies show that this spa may have positive effects in the treatment of psoriasis. It was also discovered that the Kangal fish spa met the balneological criteria and contained more of the listed therapeutic ingredients.