Three-dimensional (3D) printing with biocompatible resins offers new competition to its opposition—subtractive manufacturing, which currently dominates in dentistry. Removing dental material layer-by-layer with lathes, mills or grinders faces its limits when it comes to the fabrication of detailed complex structures. The aim of this original research was to design, materialize and clinically evaluate a functional and resilient shape of the orthodontic power-arm by means of biocompatible 3D printing. To improve power-arm resiliency, we have employed finite element modelling and analyzed stress distribution to improve the original design of the power-arm. After 3D printing, we have also evaluated both designs clinically. This multidisciplinary approach is described in this paper as a feasible workflow that might inspire application other individualized biomechanical appliances in orthodontics. The design is a biocompatible power-arm, a miniature device bonded to a tooth surface, translating significant bio-mechanical force vectors to move a tooth in the bone. Its design must be also resilient and fully individualized to patient oral anatomy. Clinical evaluation of the debonding rate in 50 randomized clinical applications for each power-arm-variant showed significantly less debonding incidents in the improved power-arm design (two failures = 4%) than in the original variant (nine failures = 18%).