This study was designed in order to estimate some immunological (IL-6 and C-Reactive Protein -CRP-), physiological (Resistin) and biochemical (Glutathione and Malondialdehyde) parameters of some patients with rheumatoid arthritis in Kirkuk city. The study involved (60) blood samples were divided into 2 groups: group one: adult normal healthy individuals as control group, group two: adult patients with rheumatoid arthritis. The results of this study found significant increase inpro-inflammatory cytokine IL-6 concentrations at levels (P≤ 0.05) of second group in comparison with control group ; and there are significant increases in adipokineresistinconcentrations at levels (P≤ 0.05) of second group in comparison with control group; and there are significant increases in CRP concentrations at levels (P≤ 0.05) of second group in comparison with control group and there are significant decreases in glutathione (GSH) concentrations at levels (P≤ 0.05) of second group in comparison with control group, and there are significant increases in malondialdehyde (MDA) concentrations at levels (P≤ 0.05) of second group in comparison with control group.