Introduction: With mandatory “Flight Nurses” during World War II, there was a need to improve aeromedical rescue. Currently, the use of aerospace removal is crucial to rapidly take away trauma patients in large urban centers. In Brazil, ABCDE system is adopted during pre-hospital care (PHC) so that nursing needs constant updating to meet the demand for care. Objective: To identify and describe role and challenges of nursing professionals in aerospace transport. Methodology: Integrative review of indexed articles in the last 10 years (2010 to 2020) with focus on pre-hospital care and nursing role. Inclusion criteria were: country of publication, Brazil was the only one considered, publication of the full text and appropriate descriptors. Exclusion criteria included: publication from other countries, absence of descriptors and duplication of articles in databases. Descriptors were crossed in either pairs or trios. Results: A total of 1306 articles on the theme were found, 16 of which were selected by contemplating the research question. However, only 13 met all requirements in the study as excluded articles (1) did not address the research problem in any aspect or (2) were themselves integrative reviews. Conclusion: More studies on needs and particularities of aerospace removal are essential for nurses in order to fill existing knowledge gaps.