Background: Lipoma is the most frequent benign mesenchymal neoplasm's that affect the human body. They are composed of mature adipocytes and are enveloped by a fibrous capsule. The oral vestibule and jugal mucosa are the most commonly affected intraoral sites, and the tumors are characterized by painless increase in size, soft consistency, yellowish color, sessile or pedunculated base, and slow growth rate. Objective: To report a case of giant facial lipoma and to review the main diagnostic and therapeutic aspects of this pathology. Case report: NRS, a 64-year-old female patient, presented with increasing facial volume for 7 years. Tumescence was observed from the genial to the mental regions, with intraoral and extra oral protuberance. Surgical removal was chosen as treatment. Final remarks: The histopathological analysis confirmed the diagnosis of lipoma. In cases of large lesions, surgery remains as the mainstay of treatment.