Background: Traditional herbs are effective in the treatment of many diseases. It is proven that traditional herbs can decrease the risk of cancer and grow the survivals of patients. Objectives: Based on the results of our previous research, ethanol Baneh skin extract has cytotoxic effect on pc3 cells; thus, we decide to determine the effect of Baneh extracts on Bcl2 and Bax expression and amount of concentration of caspase3. Methods: The expressions of apoptotic -related genes were determined by real time PCR and the concentration of caspase3 was determined by ELISA method. Results: Ethanol Baneh skin extract increased the mRNA expression of Bax and decreased the mRNA expression of Bcl2 in pc3 cells and also increased the amount of caspase3. Conclusions: The result of this study indicates the Ethanol Baneh skin extract including photochemical that might be a candidate for the herbal anti -cancer drugs.