Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome (PFAPA) is characterized by periodic cyclical fever, cervical adenopathy, pharyngitis, and aphthous stomatitis. Administration of oral corticosteroids at the onset of fever is the current initial treatment. Tonsillectomy resolves PFAPA symptoms in 50-100% of patients. Objective: The goal of this retrospective observational study was to characterize aspects of PFAPA patients seen at a medium size children's hospital between 2008 and 2016 and evaluate treatment outcomes.