Exploiting the properties of quantum information to the benefit of machine learning models is perhaps the most active field of research in quantum computation. This interest has supported the development of a multitude of software frameworks (e.g. Qiskit, Pennylane, Braket) to implement, simulate, and execute quantum algorithms. Most of them allow us to define quantum circuits, run basic quantum algorithms, and access low-level primitives depending on the hardware such software is supposed to run. For most experiments, these frameworks have to be manually integrated within a larger machine learning software pipeline. The researcher is in charge of knowing different software packages, integrating them through the development of long code scripts, analyzing the results, and generating the plots. Long code often leads to erroneous applications, due to the average number of bugs growing proportional with respect to the program length. Moreover, other researchers will struggle to understand and reproduce the experiment, due to the need to be familiar with all the different software frameworks involved in the code script. We propose QuASK, an open-source quantum machine learning framework written in Python that aids the researcher in performing their experiments, with particular attention to quantum kernel techniques. QuASK can be used as a command-line tool to download datasets, pre-process them, quantum machine learning routines, analyze and visualize the results. QuASK implements most state-of-the-art algorithms to analyze the data through quantum kernels, with the possibility to use projected kernels, (gradient-descent) trainable quantum kernels, and structure-optimized quantum kernels. Our framework can also be used as a library and integrated into pre-existing software, maximizing code reuse.