Sensory rooms could provide occupational therapists with a valuable tool for reducing distress for adolescents in psychiatric units, especially for those with a history of aggression. Results suggested that female adolescents or adolescents with anxiety disorders may be particularly receptive to using the sensory room. This research provides evidence that can inform occupational therapists when tailoring therapeutic treatment strategies and guide the development of prevention and management of emotional dysregulation and aggression within adolescent psychiatric settings.