Quinidine is cited as one of the most frequent causes of drug-induced thrombocytopenia. This case report describes the use of high-dose intravenous gamma globulin to rapidly reverse quinidine-induced thrombocytopenia in a patient at increased risk for bleeding because of the presence of an antitachycardia pacemaker and an automatic implantable cardiac defibrillator. This report suggests that this treatment may aid in a more rapid reversal of quinidine-induced thrombocytopenia in patients at high risk of bleeding.

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