The Quiçama National Park (PNQ), located in Luanda Province, Angola, is one of the oldest protected areas in the country. Although some work has been done on the flora of the Park, up to now a comprehensive record of the vascular plant species has been lacking. The objective of the present study was to produce an inventory of the vascular plant diversity of PNQ, as well as to record the types of vegetation in which each species occurs, their habits, uses by local communities, common names, and conservation status. A total of 452 species were recorded, from 285 genera and 85 families. Two species are Pteridophytes, 99 are Monocotyledons, and 351 are Dicotyledons. The two largest families of the PNQ flora are the Fabaceae and the Poaceae. The Park hosts 14 species endemic to Angola, and one of them is restricted to this protected area. Of the 128 species with data on conservation status, 109 are considered of least concern, 13 are vulnerable, and six are endangered. Regarding useful plants, 237 species from 67 families were recorded. Of these, 196 are Dicotyledons and 41 are Monocotyledons. Most of them are used for medicinal purposes, the manufacturing of artefacts, and as sources of food.