Corrosion inhibitors can trigger health and/or environmental problems due to their toxicity. For this reason, it has been suggested to use plant extracts as natural corrosion inhibitors, because they represent a rich source of chemical compounds, they are non-toxic, biodegradable and abundant in nature. Sorghum halepense is a herbaceous weed, commonly known as johnson grass, belongs to the family gramíneae or poaceae, the choice of this plant is due to its zero cost and easy availability. In this systematic review, were used keywords such as Sorghum halepense johnson grass, phytochemistry, phytotherapy, phytoremediation, antidiabetic, antioxidant, cytotoxicity, antifungal, antimicrobial, anticancer, biological activity, medical activity, allelochemicals, among others. To do this, were used databases such as Scielo, Dialnet, Redalyc, Google Scholar, DOAJ, Wiley online library, BioOne, EBSCOHost, Knovel, ScienceDirect, SpringerLink y VirtualPro. Previous studies on this weed have reported its therapeutic potential against cancer, diabetes, prostatitis, hepatoprotective activity, antioxidant, antimicrobial, antifungal, as well as abortifacient and placental delivery in veterinary medicine. In view of the numerous organic molecules present in this plant, this study proposes Sorghum halepense as a potential natural corrosion inhibitor.