Objectives: To assess the epidemiological features of 76 KPC producing K. pneumoniae isolates (KPC-Kp) recovered in 3 hospitals of Buenos Aires, Argentina, during 2015-2017. Methods: Antimicrobial susceptibilities were determined according to CLSI. Molecular typing of KPC-Kp was performed by PFGE-XbaI and MLST. Plasmid encoded genes involved in carbapenem, fosfomycin and colistin resistance were detected by PCR and sequencing. Also mgrB inactivation was investigated in those colistin resistance isolates. Genetic platforms involved in horizontal spread of bla KPC were investigated by PCR mapping.Results: Besides β-lactams, high resistance rates were observed for gentamycin, quinolones and trimethoprim-sulfamethoxazole. KPC-Kp ST258 corresponded to

There has been a decline in the total number of cases of neonatal conjunctivitis, but the disease is still an important health problem. Chlamydia trachomatis also shows a decreasing profile with an incidence of (cases per 1000 live births) 4.39 in 1995, 1.85 in 1996, 1.01 in 1997, and 0.78 in 1998, and a tendency to show more incidence in spring-summer and significant accumulation of cases in babies between 7 and 9 days of age. Haemophilus influenzae alone (12.3%) or associated with S. pneumoniae (4.5%) appears as a prevalent potential bacterial pathogen. A significant accumulation of H. influenzae and S. pneumoniae cases occurs in winter. In 47.6% of cases, there was no bacterial growth. No significant seasonal differences in percentage of negative cultures or among the three-day age groups were detected. Neisseria gonorrhoeae was not found associated with ophthalmia neonatorum in this series.

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Ten IMP-8-producing isolates were recovered from surveillance cultures of a neonatal intensive care unit; eight of the isolates were clonally related. A 168.2-kb plasmid was fully sequenced, and it corresponded to the recently described IncA/C1-ST13 plasmid. This plasmid was detected in all isolates, even in those that were not clonally related. One unrelated isolate was also resistant to colistin and positive for This marker was located in a 62.7-kb IncI2 plasmid, which was also fully sequenced.

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