A murine model of ataxia telangiectasia was created by disrupting the Atm locus via gene targeting. Mice homozygous for the disrupted Atm allele displayed growth retardation, neurologic dysfunction, male and female infertility secondary to the absence of mature gametes, defects in T lymphocyte maturation, and extreme sensitivity to gamma-irradiation. The majority of animals developed malignant thymic lymphomas between 2 and 4 months of age. Several chromosomal anomalies were detected in one of these tumors. Fibroblasts from these mice grew slowly and exhibited abnormal radiation-induced G1 checkpoint function. Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder.
The above results clearly demonstrate that a well-equipped and properly manned HDU can greatly facilitate management of high-risk cases with favourable outcome. It provides excellent pain control facilities, detects complications early and avoids unnecessary ITU admissions. It also provides an excellent training opportunity for both medical and nursing staff.
This is an easy and safe technique resulting in a stable and satisfactory reconstruction after large antero-lateral full-thickness chest wall resections involving the diaphragm.
Arterial healing after laser treatment: F. W. Cross et a\. Quantum Electron 1984; Q E 20: 1471-81. Priebe LA, Cain CP, Welch AJ. Temperature rise required for production ofminimal lesions in the Macaca Mulatta retina. Am J Ophthalmol 1975; 79: 405-13. Boulnois J-L. Photophysical processes in recent medical laser developments: a review. Lasers Med Sci 1986; 1: 47-68. Abela GS, Crea F, Seeger JM et a / . The healing process in normal canine arteries and in atherosclerotic monkey arteries after transluminal laser irradiation. Am J Cardiol 1985; 56: 983-8. Crawford T. The healing of puncture wound in arteries. J Path Bacteriol 1956: 72: 547-52. 25. 26. 27. 28. 20. 21. 22. 23. 24. Eugene J, McColgan SJ, Pollock ME et al. Experimental arteriosclerosis treated by argon ion and Nd-YAG laser endarterectomy. Circulation 1985; 72(Suppl 11); 2 W 6 . Lee G, Ikeda RM, Theis JH et al. Acute and chronic complications of laser angioplasty : vascular wall damage and formation of aneurysms in the atherosclerotic rabbit. Am J Cardiol 1984; 53: 29C3. Helwig EB, Jones WA, Hayes JR, Zeitler EH. Anatomic and histochemical changes in skin after laser radiation. Fed Proc 1965; Cross FW, Bowker TJ, Boon SG. The role of pulse length in limiting distant tissue damage caused by Nd-YAG laser validation in vascular tissue. Lasers Med Sci 1986; 1: 315. Welch AJ. The thermal response of laser-irradiated tissue. IEEE J 24(S~ppl 14): 583-91.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.