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Vol. 70 with diethanolamine and with dichlorodiethylamine to give the corresponding urea derivatives, and also with thiodiglycol to give a product which after treatment with thionyl chloride yields chloroethylthio substituted benzanthranylmethylurethan.Certain rationalizations are presented with regard to the interest in the ß-chloroethyl substituted derivatives as possible agents in a study of chemotherapy of cancer.Cambridge 38, Massachusetts

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Erythraline, CigHjgNOs, contains one methoxy group and a methylenedioxy group. The nitrogen atom is tertiary, and in all probability is common to two nuclei of the molecule, since it was shown that the tetrahydro derivative was identi-cal with dihydroerythramine. The unsaturation consists of two ethylenic double bonds and one benzenoid nucleus. Erythramine and erythraline appear to contain four nuclei exclusive of the methylenedioxy bridge.The ultraviolet absorption spectra of these two alkaloids and dihydroerythramine were determined and the spectrum of the latter was found to be very similar to that of 6,7-methylenedioxy-1,2,3,4-tetr ahy droiso quinoline.Hydrastic acid was obtained from the oxidation of erythraline methohydroxide with potassium permanganate.Nuclear formulations for erythramine and erythraline are suggested on the basis of the present facts.Rahway, N. J.

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