Sir: Until recently the desorption of ions of bioorganic compounds in the mass range above 10 000 daltons seemed to be exclusively the domain of plasma desorption mass spectrometry (PDMS) (1-4). In 1987 Tanaka et. al. ( 5) reported laser desorption of protein molecular ions up to a mass of 34000 daltons. Oligomers of lysozyme containing up to
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