The ACS Green Chemistry Institute® Pharmaceutical Roundtable has assembled an updated list of key research areas to highlight transformations and reaction media where more sustainable technologies would be most impactful.

±)-(Z)-pent-3-en-2-ol, 60102-80-9; (E)-cinnamyl alcohol, 4407-36-7; (Z)-cinnamyl alcohol, 4510-34-3; (E) -3-(1,3-benzodioxol-5-yl)prop-2-en-l-ol, 58095-76-4; (Z)-3-(l,3-benzodioxol-5-yl)prop-2en-l-ol, 90359-53-8; (±)-(E)-l-methyl-3-phenylprop-2-en-l-ol, 84519-62-0; (±)-(E)-2-methylhept-5-en-4-ol, 109214-86-0; (±)-(Z)-2-methylhept-5-en-4-ol, 64727-70-4; (±)-(Z)-dec-2-en-4-ol, 109087-97-0; (E)-l-bromopropene, 590-15-8.

The utility of 1,5,7-triazabicyclo[4.4.0]dec-5-ene as a reagent to facilitate efficient amide formation by reaction of an amine with an unactivated ester was demonstrated on pilot-plant scale as a key step in the synthesis of an H-PGDS inhibitor.