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Amino acids Amino acids U 0400Novel Antifungal β-Amino Acids: Synthesis and Activity Against Candida albicans. -A variety of novel β-amino acids are synthesized and evaluated for their in vitro antifungal activity against Candida albicans. Compound (VIII) appears to be equipotent to cispentacin and exhibits the most favorable activity-tolerability profile among all β-amino acids synthesized so far. Key step in the synthesis of (VIII) is a highly enantioselective, quinine-mediated alcoholysis of the meso-anhydride (V). -(MITTENDORF*, J.; KUNISCH, F.; MATZKE, M.; MILITZER, H.-C.; SCHMIDT, A.; SCHOENFELD, W.; Bioorg. Med. Chem. Lett. 13 (2003) 3, 433-436; Inst. Med.

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