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A patient with basal-cell epithelioma occurring in a sm all pox vaccination site is reported. The association is pro b ably not a chance occurrence. M a l i g n a n t TUMORS arising in smallpox vaccination sites are relatively rare occurrences'. Basal-cell epitheliomas and squamous-cell carcinomas2 have predominated in in cidence; melanomas have occurred; and one instance of a dermatofibrosarcoma protuberans and another of a mesen chymoma at the site of an injection of insulin has been reported3. Vaccination with BCG has been followed by the development of a malignant melanoma4.The case reported here is the 51st of malignancy de veloping in a scar of smallpox vaccination. nation had been asymptomatic until a nodule began to de velop one year ago.On examination, a 9 x 10 mm nodular and erythematous lesion was found on the left deltoid region within the borders of a depressed scar (Fig. 1). ___ M . 1 ■ w ËiÊÊÈÊÈÊBÊÈ if m m m m F IG U R E 1. Nodule in a vaccination scar on the left deltoid region.

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