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1. The acute oral LD50 of poinsettia in Sprague Dawley rats were greater than 25 gm/kg for all plant parts tested. 2. Exaggerated oral dosing over a five-day period with as much as 125 gm/kg total dose did not produce any gross or microscopic pathology in Sprague Dawley rats. 3. A five-day total diet study of poinsettia produced no gross pathology in Sprague Dawley rats. 4. Poinsettia latex induced no local toxicity when instilled into the buccal cavity of Sprague Dawley rats. 5. Poinsettia latex induced no damage when instilled into the eyes of albino rabbits. 6. Upon repeated exposures poinsettia exhibited mild skin irritation in the albino rabbit. It is not considered to be a primary irritant. 7. Poinsettia induced skin photosensitivity in albino rabbits.