Pyruvate Dehydrogenase Complex (PDC), a mitochondrial matrix enzyme, converts pyruvate, the end product of cytoplasmic glycolysis, into acetyl-coenzyme A which is further metabolized in the citric acid cycle. PDC consists of a thiamine diphosphate-dependent pyruvate dehydrogenase (PDH), a heterotetramer of 2α and 2β subunits (α 2 β 2 ); dihydrolipoamide acetyltransferase, and FAD-containing dihydrolipoamide

During development, the Neuro-Epithelial Cells (NECs) give rise to the primary stem-cells (NSC), the apical radial glia (aRG) [4]. As the brain develops, aRGs will become confined to the primary cortical germinal layer, known as the ventricu-