High mortality and dissemination rates of the emerging virus TiLV (Tilapia lake Virus) leads the researcher to develop a novel strategies to prevent these kind of infections in the fish. In viral diseases, vaccination is the most recommended method for prevention. In this context and considering the genome sequences of TiLV virus published in the article “Complete Genome Sequence of a Tilapia Lake Virus Isolate Obtained from Nile Tilapia (Oreochromis niloticus)”, we propose to produce a recombinant oral vaccine through microalgae biotechnology using viral vectors.