The seed of Hyptis suaveolens , commonly known as wild flour ball (san fen yuan) in Taiwan, serves as a main refreshing drink substance in several regions. This study investigated firstly its secondary metabolites, leading to the isolation of five major caffeoylquinic acid derivatives ( 1–5 ) from the ethanol extract. In addition, ten minors, including three caffeoylquinic acid derivatives ( 12–14 ), were characterized via assistance of HPLC-SPE-NMR. Of these isolates, sodium 4,5-dicaffeoylquinate ( 2 ) and methyl 3,5-dicaffeoylquinate ( 4 ) showed moderate inhibitory activity against xanthine oxidase with the respective IC 50 values of 69.4 μM and 92.1 μM ( c.f. allopurinol IC 50 28.4 μM). Quantitative HPLC analysis of the EtOH extract indicates the content of sodium 3,5-dicaffeoylquinate ( 1 ) and sodium 4,5-dicaffeoylquinate ( 2 ) to be 0.1% and 0.08% (w/w, dry seed), respectively. This study not only discloses the bioactive constituents, but also demonstrates the potential of H. suaveolens seed as an antihyperuricemic nutraceutical.

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