Without using any additives, a practical and eco-friendly methodology has been realized for the tandem double cyclization of 1,6-dienes with easily accessible azobis(alkylcarbonitriles) on water.

A concise and eco-friendly acylation/cyclization of 1,6-dienes with linear ethers under catalyst- and base-free conditions has been developed.

A copper-catalyzed cascade cyclization of 1,6enynes with sulfonyl hydrazides for producing various sulfonyl-substituted γ-lactams is described. This sulfonyl radical-enabled cyclization reaction features excellent regioselectivity, mild conditions and broad substrate scope, enabling the formation of new CÀ S and CÀ C bonds through radical sulfonylation, intramolecular cyclization and hydrogen abstraction. Moreover, relevant experiments have been carried out to probe a possible mechanism.

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